TY  - JOUR
AB  - Anorexia Nervosa (AN) is associated with high somatic comorbidities. Among them, impaired renal function is frequently overlooked by physicians. Since a high rate of individuals affected by AN may become chronically ill, assessing renal function is crucial to prevent further deterioration of the kidney-related condition. An accurate evaluation of GFR is also critical to prevent drug toxicity and to provide appropriate protein requirements during nutritional rehabilitation. Furthermore, optimizing protein intake is key to a positive protein balance and to promote muscle anabolism. Literature is scarce and no univocal guidelines exists to define how to estimate GFR in those patients. Equations relied on serum creatinine may not be accurate to estimate GFR in AN patients, especially in case of cachexia. We therefore describe the case of a women with a 22 year-history of anorexia nervosa, in which eGFR based on serum creatinine was falsely normal and impaired renal function was revealed by unusual electrolytes disturbances. In conclusion, we think clinicians should consider collecting 24-hour urine and calculate creatinine clearance to correctly assess renal function. Dedicated guidelines are needed to define the optimal daily protein intake in malnourished patients with AN and CKD during weight gain and weight maintenance phases.
AU  - Onfiani, G.
AU  - Carubbi, F.
AU  - Pellegrini, E.
DA  - 2020/12/22
DO  - 10.32044/ijedo.2020.08
KW  - Anorexia nervosa
Eating disorders
Kidney
Renal function
Creatinine clearence
Protein requirements
L1  - internal-pdf://3829176269/202008.pdf
M3  - Original article
PY  - 2020
SE  - 43
SN  - 2612-6354
SP  - 43-48
ST  - Evaluating renal function and defining protein requirements in patients affected by anorexia nervosa: a case report
T2  - IJEDO
TI  - Evaluating renal function and defining protein requirements in patients affected by anorexia nervosa: a case report
VL  - 2
ID  - 2526
ER  -